Dr. Ross Grant is Clinical Associate Professor at the University of Sydney Medical School and CEO of the Australasian Research Institute, Sydney Adventist Hospital.
A biochemical pharmacologist with a Ph.D. in Neurochemistry/Neuropharmacology, Dr. Grant’s research is focused on NAD—specifically the role of oxidative stress—e.g. emotional stress, diet, and exercise—and NAD metabolism on brain cell death and cellular degeneration. A secondary interest is in the effect of exposure to novel nutritional components, such as poly phenols, on human cellular response to oxidative stress, with a goal of detecting and correcting early degenerative biochemical changes associated with aging-related degenerative disease.
With forty-eight articles published in peer-reviewed scientific journals, Dr. Grant is perhaps the most prolific author in the field of NAD research. He is the guest editor of Cells’ special issue on NAD+ metabolism and cell signaling (January – August 2015) and on the editorial board of the International Journal of Tryptophan Research. Other NAD-specific research publications to which he has contributed include “Lycopene Pre-Treatment Ameliorates Acute Ethanol Induced NAD+ Depletion in Human Astroglial Cells.” Oxidative Med. Cellular Longevity (in press, May 2015); “Changes in oxidative damage, inflammation, and [NAD(H)] with age in cerebrospinal fluid,” PLoS One, 2014, vol. 9, no. 1, pp. e85335, http://dx.doi.org/10.1371/journal.pone.0085335; “Cerebrospinal fluid levels of inflammation, oxidative stress and NAD+ are linked to differences in plasma carotenoid concentrations.” J. of Neuroinflammation, 11:117- 2014; “Mapping NAD(+) metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence,” Biogerontology, vol. 15, no. 2, pp. 177 – 198, http://dx.doi.org/10.1007/s10522-013-9489-5; “Serum Nicotinamide Adenine Dinucleotide Levels Through Disease Course in Multiple Sclerosis.” Brain Research Aug 21. pii: S0006-8993(13)01147-5. doi: 10.1016/j.brainres.2013.08.025; “Resveratrol Increases Intracellular NAD+ Levels Through Up regulation of The NAD+ Synthetic Enzyme Nicotinamide Mononucleotide Adenylyltransferase.” Nature Precedings 2010. http://precedings.nature.com/documents/4421/version/1; “The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD(+)(H). (vol 2, pg 319, 2010),” presented at http://dx.doi.org/10.3390/nu2040481; “Effects of Kynurenine Pathway Metabolites on Intracellular NAD+ synthesis and Cell Death in Human Primary Astrocytes and Neurons.” Int J. Tryp. Res.2:61-69 2009; “Promotion of Cellular NAD+ Anabolism: Therapeutic Potential for Oxidative Stress in Ageing and Alzheimer’s Disease” (Review); Neurotox. Res. 2008; 13 (4):1-12; and “Increased de novo synthesis of NAD in immune activated astrocytes and macrophages cell lines,” presented at 2nd Biannual Kynurenine Meeting, University of Sydney, 4 December 1999. Other article publications include the Journal of Cellular Biochemistry, Transfusion, Nutrition Research, Cur. Topics Medicinal Chemistry, Int. J. Child Health & Nutrit., Nutrit & Metab., Lipids in Health and Disease, Cancer Research, Int J Nutr Pharmacol Neurol Dis., and more.
He has presented at sixty research conference s, is invited to speak at more than thirty seminars a year, and is a frequent guest on television and radio programs on health, wellness, nutrition, and results of his current research.
Dr. Grant is a member of the Australian Society for Medical Research (ASMR), Australian Neuroscience society (ANS), Australian Society of Clinical & Experimental Pharmacology and Toxicology, Nutrition Society of Australia (NSA).